The Brooks Glycerin line has been a staple for runners seeking plush cushioning and reliable support. With the release of the Brooks Glycerin 21, many are wondering if this latest version truly improves on its predecessors and if it’s worth the upgrade. In this full review, we’ll break down the key features, performance, comfort, and value of the Glycerin 21 to help you decide whether it deserves a spot in your running shoe rotation.

1. Design and Aesthetics
The Brooks Glycerin 21 sports a sleek, modern look while maintaining the classic silhouette loved by many runners. The updated engineered mesh upper offers enhanced breathability and a refined fit, featuring seamless overlays that reduce irritation. Available in a variety of colorways, the shoe balances style and function for both casual wearers and serious runners.
2. Improved Cushioning with DNA LOFT v3
One of the standout upgrades in the Glycerin 21 is the use of DNA LOFT v3 foam in the midsole. This latest cushioning technology delivers:
- Softer underfoot feel without sacrificing responsiveness
- Better energy return to aid forward propulsion
- Improved durability for long-lasting comfort
Runners report a noticeably plush ride that cushions impact, making it ideal for long-distance training and recovery runs.
3. Fit and Comfort
The Glycerin 21 features an adaptive heel collar that hugs the heel comfortably to prevent slipping, enhancing stability. The padded tongue and collar add extra comfort, while the roomy toe box allows natural toe splay without feeling loose. Overall, the shoe provides a secure yet forgiving fit suitable for various foot shapes.
4. Performance and Ride Quality
On the road, the Glycerin 21 impresses with its smooth transitions and balanced cushioning. The midsole’s softness helps absorb shock during heel strikes, while the shoe’s Meta-Rocker geometry promotes efficient toe-off. Whether running short intervals or logging marathon miles, the Glycerin 21 supports a comfortable and consistent stride.
5. Durability and Outsole
The outsole features a durable rubber compound with a redesigned traction pattern that offers reliable grip on wet and dry pavement. Early testers praise the Glycerin 21 for maintaining its cushioning and outsole integrity well past 300 miles, aligning with Brooks’ reputation for longevity.
6. Comparing to the Glycerin 20
Compared to the Glycerin 20, the Glycerin 21 provides:
- Noticeably softer midsole cushioning
- More breathable and flexible upper materials
- Enhanced heel fit with the adaptive collar
- Slightly lighter overall weight
These improvements make the upgrade appealing for runners who value plush comfort and a more modern feel.
7. Price and Value
The Brooks Glycerin 21 is positioned at a premium price point, typical of high-end running shoes. While it’s more expensive than entry-level models, its combination of comfort, durability, and advanced tech justifies the investment for dedicated runners. Occasional discounts and sales can make it more accessible.
Final Verdict: Is the Brooks Glycerin 21 Worth the Upgrade?
If you already love the Brooks Glycerin series, the 21st iteration delivers meaningful enhancements in cushioning, fit, and breathability that justify the upgrade. Its plush ride and durability make it an excellent choice for long-distance runners or anyone seeking maximum comfort on their feet.
For runners new to the Glycerin line, the Glycerin 21 stands strong as a premium cushioned running shoe that rivals the best in its category. Overall, it’s a worthy investment for those prioritizing comfort, support, and reliable performance in their running footwear.